A monoclonal macroglobulin with antinuclear activity.
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چکیده
منابع مشابه
A monoclonal macroglobulin with antinuclear activity.
Serum containing a monoclonal IgM protein from a patient with Waldenstroms' macroglobulinaemia gave intense immunofluorescent staining of kidney nuclei. The Fab mu fragments of this immunoglobulin were obtained. The IgM and Fab fragments reacted in vitro with kidney nuclei using unfixed cryostat sections of rat or mouse kidney. After treatment of the patient with chemotherapy, the monoclonal Ig...
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A monoclonal macroglobulin from a patient with Waldenström macroglobulinemia has been shown to have antiglobulin activity of a new type, namely, that of a true anti-antibody. The protein reacts with human, primate, and rabbit IgM and IgG, only when the target immunoglobulin is complexed to an antigen. The implications of the general findings of antiglobulin activity of monoclonal proteins is di...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1979
ISSN: 0021-9746
DOI: 10.1136/jcp.32.5.450